Basic Research Tips: Molecular & Cell Biology
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This Research Tips guide for Molecular & Cell Biology includes the following sections and modules.
We recommend viewing ALL 4 modules of the tutorial in order, to improve comprehension of the concepts.
1. I'm new to a field - I just want pivotal papers:
- Try Google Scholar
- Try Web of Science
Example: When did Resveratrol hit "prime time" and which paper about it has been most widely cited?
2. I have a sequence and I'd like to align it with known sequences and review those sequences:
- Try Blast Nucleotide
Example: What gene does the following sequence come from? What obscure genetic disorder is it associated with?
gggtgaacag ccgcacggga gtaggtacgc acctgacctc
gctggcactg ccgggcaagg cagagggtgt ggcgtcgctc
accagccagt gcagctacag cagcaccatc gtccatgtgg
gagacaagaa gccgcagccg gagttagaga tggtggaaga
3. I want to learn more about a specific gene and it's associations with diseases and phenotypes:
- Try the Gene Database
- Try OMIM from the Gene Database
- Try PubMed
Example: A portion of what gene is missing in 5q deletion syndrome? What broad type of illness is caused by 5q(-)? What eponymously named genetic disorder is located very close to 5q(-)?
4. I want to learn how to view 3-D structures of genes
Translational Informatics Video Learning Resources (click cancel and ignore the login box)
NCBI Practice Exercises from the "Introduction to Molecular Biology Information Resources" course, if you'd like to try more databases and examples.
- Complete set of mastery exercises on the PER2 gene (circadian rhythms) from all modules.
- Complete set of demonstration exercises on the MLH1 gene (colon cancer) from all modules.
Special thanks to Hannah Tipney, PhD. (Center for Computational Pharmacology, CU Denver, Anschutz Medical Campus) for creating the list of questions new researchers might have that forms the basis for this tutorial.
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